Program

SITPM2019 Program

Monday, May 13
Time	Session/Lecture info
12:00-14:00	Registration, exhibition & Lunch
12:00-14:00
14:00-16:50	Opening Session Chair: Yosef Yarden
14:00-14:10	Welcome and opening notes by organizers
14:10-15:00	Lisa Coussens , OHSU, USA Neutralizing Protumor Inflammation: Lessons Learned from Preclinical Mouse Models
15:00-15:30	Coffee Break
15:30-15:55	Jeff Pollard , University of Edinburgh, UK Macrophages; Bad actors in human and mouse cancer
15:55-16:10	Ariel Munitz, Tel Aviv University Short talk: Activated eosinophils exert antitumorigenic activities in colorectal cancer
16:05-16:25	Serena Vegna , The Netherlands Cancer Institute Short talk: Exploiting senescence for the treatment of liver cancer
16:25-16:50	Massimiliano Mazzone , VIB/KU Leuven, Belgium Podoplanin-expressing macrophages: a "PoEM" on breast cancer metastasis
16:50-18:30	Poster session I
16:50-18:30
18:30-21:00	Reception Cocktails and Dinner
18:30-21:00

Tuesday, May 14
Time	Session/Lecture info
08:00-09:00	Registration & Refreshments
08:00-09:00
09:00-14:00	The inflammatory microenvironment Chair: Adit Ben Baruch
09:00-09:25	Eli Pikarsky , Hebrew University of Jerusalem, Israel Pro and Anti Tumorigenic Functions of Tertiary Lymphoid Structures
09:25-09:50	Karin de Visser , Netherlands Cancer Institute, Netherlands Dissecting cancer cell-intrinsic mechanisms dictating the pro-metastatic immune landscape of breast cancer
09:50-10:05	Ido Yofe, Weizmann Institute of Science Short talk: Single-cell analysis illustrates discrete immune cell dynamics generated by a checkpoint blocking aCTLA4 vs. a dual-function aCTLA4 with blocking and FcgR engagement activity
10:05-10:30	Zvika Granot , Hebrew University of Jerusalem, Israel Epithelial-to-Mesenchymal Transition and Tumor Cell Susceptibility to Neutrophil Cytotoxicity
10:30-11:00	Coffee break
11:00-11:25	Florian Greten , Georg-Speyer-Haus Institute, Frankfurt, Germany CAFs, stemness and tumor progression in CRC
11:25-11:50	Mikala Egeblad , CSHL, USA Neutrophil extracellular traps produced during inflammation awakens dormant cancer cells
11:50-12:05	Ronen Alon, Weizmann Institute of Science Short talk: A-type nuclear lamins restrict melanoma metastasis to lungs
12:05-12:10	Wietske Pieters, Netherlands Cancer Institute Falsh talk: Intestinal tumor development in Lynch Syndrome: a role for the microbiota?
12:10-14:00	Lunch Break
14:00-16:55	Tumour adaptation to stress Chair: Alexia-Ileana Zaromytidou
14:00-14:25	Ayelet Erez , Weizmann Institute of Science, Israel Targeting amino acid metabolism under nutrient stress for cancer therapy
14:25-14:40	Raquel Blazquez, University Hospital Regensburg Short Talk: Metastatic brain colonization, a major determinant of survival, is supported by LEF1-regulated glutathione metabolism in breast cancer
14:40-15:05	Celeste Simon , University of Pennsylvania, USA Metabolic Transitions in the Tumor Microenvironment
15:05-15:35	Coffee Break
15:35-16:00	Guido Kroemer , INSERM, France Immunogenic cell death ? how tumor cells escape from immune detection
16:00-16:15	Shamgar Ben-Eliyahu, Tel Aviv University Short talk: Phase II clinical trials in colorectal and breast cancer patients: Perioperative pharmacological blockade of inflammatory and stress responses improves biomarkers of metastasis in excised tumors and i
16:15-16:40	Eyal Gotlieb , Technion, Israel Metabolic and genetic response to prolonged resource exhaustion
16:40-16:45	Tomer Cooks, Ben-Gurion University of the Negev Flash talk: Mutant p53 as a master regulator of immune dynamics driving tumorigenesis via exosomes
16:45-16:50	Asaf Madi, Tel Aviv University Flash talk: Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1-CD8+ Tumor-Infiltrating T Cells
16:50-16:55	Yulia Liubomirski, Tel Aviv University Flash talk: Tumor-stroma-inflammation networks promote pro-metastatic characteristics in triple-negative breast cancer by activating the Notch pathway
16:55-18:30	Poster session II
16:55-18:30
18:30-20:00	Gala Dinner
18:30-20:00

Wednesday, May 15
Time	Session/Lecture info
08:00-08:30	Registration & Refreshments
08:00-08:30
08:30-12:25	Tumor-stroma coevolution Chair: Yinon Ben-Neriah
08:30-09:00	Poster Setup
09:00-09:50	Michael Karin , UCSD, USA Metabolic stress in the initiation and progression of liver cancer
09:50-10:15	Laurence Zitvogel , Gustave Roussy, France Molecular mimicry between gut microbiota and cancer antigens
10:15-10:30	Nir Ben Chetrit, Weill Cornell Medicine, New York, USA Short talk: Organoid Modeling of Innate Immunity in Microenvironment of Breast Cancer
10:30-10:50	Coffee Break
10:50-11:15	Ruth Scherz-Shouval , Weizmann Institute of Science, Israel Cancer-associated fibroblast heterogeneity in breast cancer
11:15-11:40	Gian-Paolo Dotto , UNIL Lusanne, Switzerland & MGH, USA CSL controls telomere maintenance and genome stability in human dermal fibroblasts and CAFs
11:40-12:05	Frances Balkwill , Barts Cancer Institute, London, UK Innate immune pathways and the matrisome in ovarian cancer
12:05-12:20	Yuval Shaked , Technion, Israel The host immunological response to anticancer drugs and its clinical implications
12:20-12:25	Ana Paula Delgado, Stony Brook University Flash talk: Discovery of Cellular Subtypes in Breast Cancer Progression by scRNA-Seq
12:25-14:00	Lunch
12:25-14:00
14:00-17:05	Tumor Metastasis
14:00-14:25	Erik Sahai , Crick Institute, London, UK STING and IRF3 function in stromal fibroblasts enables sensing of genomic stress in cancer cells
14:25-14:50	Neta Erez , Tel Aviv University, Israel Fibroblasts shape the inflammatory niche in breast cancer metastasis
14:50-15:15	Ron Apte, Ben Gurion University of the Negev, Israel The role Interelukin-1 (IL-1) beta in tumor invasiveness and immunotherapeutic effects of its neutralization
15:15-15:30	Bernardo Tavora, Rockefeller University Short Talk: Tumoural induction of an axon-guidance signal in the endothelium drives metastasis
15:30-15:50	Coffee Break
15:50-16:15	Ronit Satchi-Fainaro , Tel Aviv University, Israel Deciphering melanoma-brain stroma interactions in three dimensions for the rational design of nanomedicines
16:15-16:40	Janine Erler , BRIC Copenhagen, Denmark ECM remodelling during cancer progression
16:40-17:05	David Lyden , Weill Cornel, USA Exosomes and exomeres promote metastasis and systemic disease
17:05-21:00	Tel Aviv Tour and dinner for invited speakers
17:05-21:00

Thursday, May 16
Time	Session/Lecture info
08:00-19:00	Excursion to Jerusalem and Dead Sea
08:00-19:00

Organizing committee

Ruth Scherz-Shouval
Weizmann Institute of Science, Israel
Neta Erez
Tel Aviv University, Israel
Alexia-Ileana Zaromytidou
Nature Cancer , UK
Sarah Seton-Rogers
Nature Reviews Cancer, UK

Coordinator & Accessibility Issues

Irit Veksler
irit.veksler@weizmann.ac.il

Program

SITPM2019 Program

Monday, May 13

Organizing committee

Coordinator & Accessibility Issues

Sponsors