Program

XVIISOCM_2019 Program

Sunday, December 8
Time	Session/Lecture info
12:00-14:00	Registration & Light lunch
12:00-14:00
14:00-14:20	Introductory Remarks and Greetings
14:00-14:20	Lili Anglister, Jerusalem - Chair of the Organizing Committee Hermona Soreq, Jerusalem - Chair of the ISCM International Advisory Board – Greetings and words in memory of Alex Karczmar Rony Paz, Rehovot - Greetings on behalf of the Weizmann Institute
14:20-15:05	Keynote EMBO session
14:20-14:25	Israel Silman , Rehovot Introduction
14:25-15:05	Jean-Pierre Changeux , Paris The EMBO Lecture: Nicotinic modulation of higher brain functions
15:05-18:15	Session 1: Nicotinic receptors – structure/function Chairs: Victor Tsetlin, Moscow & Sara Fuchs, Rehovot
15:05-15:25	Ryan Hibbs , Dallas Atomic-scale mechanisms of nicotine at the nicotinic acetylcholine receptor
15:25-15:45	Pierre-Jean Corringer , Paris Pharmacological investigation of the fifth subunit of nAChRs
15:45-16:05	Thomas Balle , Sydney Insights in α4β2 nAChR modulation from mutational studies and molecular dynamics simulations
16:05-16:35	*Coffee break*
16:35-16:55	Roger L Papke , Gainesville Allosteric activation of nicotinic acetylcholine receptors
16:55-17:15	Victor Tsetlin , Moscow Three-finger proteins from snakes and humans acting on nicotinic receptors: old and new
17:15-17:35	Andreas Meisel , Berlin Stroke immunology – a cholinergic perspective
17:35-17:55	Edna Pereira , Baltimore A Tribute to Edson Albuquerque?s Life and Research
17:55-18:15	Michael London , Jerusalem The functional role of cortical CHAT-expressing neurons in comparison to other local CHAT neurons in the forebrain
18:15-20:15	Cocktail reception
18:15-20:15

Monday, December 9
Time	Session/Lecture info
08:00-08:30	Registration & coffee
08:00-08:30
08:30-10:20	Session 2: Presynaptic Chairs: Ran Zichel, Ness Ziona & R Jane Rylett, London, ON
08:30-08:50	Eran Elinav , Rehovot Microbiome interactions in health and disease
08:50-09:10	Randy Blakely , Jupiter, FL Presynaptic choline transporters: from gene to disease and back
09:10-09:30	R. Jane Rylett , London, ON Functional roles for 82-kDa choline acetyltransferase in health, aging and pathology
09:30-09:50	Hiroshi Nishimune , Kansas City Molecular structures organizing synaptic vesicle release sites of neuromuscular junctions analyzed using multi-color super-resolution microscopy
09:50-10:20	*Coffee break*
10:20-12:10	Session 3: Neuromuscular junction Chairs: Claire Legay, Paris & Karl Tsim, Hong Kong
10:20-10:40	Jack McMahan , College Station, TX Structure and function of active zone material at the neuromuscular junction
10:40-11:00	Steve Burden , New York Forming and maintaining neuromuscular synapses
11:00-11:20	Claire Legay , Paris The roles of ColQ, a synaptic collagen at the neuromuscular junction: lessons from the pathophysiology
11:20-11:40	Lin Mei , Cleveland Molecular mechanisms of neuromuscular junction formation and maintenance
11:40-12:00	Stephan Kröger , Planegg-Martinsreid Cholinergic modulation of muscle spindle responses to stretch
12:00-12:10	*Short breather*
12:10-13:00	Poster highlights (9 presenters) Chair: Terry Rosenberry, Jacksonville
12:10-13:00	Tamara Zorbaz, Croatia Yiyun Liu, China Bavat Bornstein, Israel Claudia Albertini, Italy Shinghung MAK, Hong Kong Dmitrii Kulbatskii, Russian Federation Maxim Bychkov, Russian Federation Edna Blotnick-Rubin, Israel Mikhail Stepanichev, Russian Federation
13:00-15:00	Lunch break & poster session (odd numbers)
13:00-15:00
15:00-17:10	Session 4: AChE – structure/function Chairs: Yves Bourne, Marseille & Joel Sussman, Rehovot
15:00-15:20	Pascale Marchot, Marseille Alpha/beta-hydrolase fold proteins: a structural motif with multiple variations and functions
15:20-15:40	Maria Laura Bolognesi , Bologna Acetylcholinesterase inhibition as a driving force in multitarget drug discovery strategies for Alzheimer’s disease
15:40-16:00	Tzviya Zeev-Ben-Mordehai , Utrecht Cryo-EM reconstruction of the human butyrylcholinesterase tetramer
16:00-16:20	Lev Weiner , Rehovot A binding site for divalent cations that stabilizes acetylcholinesterase
16:20-16:40	Terry Rosenberry , Jacksonville D2O effects on reactivation of organophosphorylated acetylcholinesterase and what they tell us about rate-limiting steps
16:40-17:10	*Coffee break*
17:10-17:55	IUBMB Jubilee session
17:10-17:15	Gabi Amitai , Rehovot Introduction
17:15-17:55	Palmer Taylor , La Jolla IUBMB Jubilee Lecture: New visions of molecular recognition of cholinergic agents through advances of technology
17:55-19:15	Session 5: AChE – nerve agents and insecticides Chairs: Zrinka Kovarik, Zagreb & Yacov Ashani, Rehovot
17:55-18:15	Zrinka Kovarik , Zagreb Reversal of OP toxicity by the oxime-assisted reactivation of acetylcholinesterase
18:15-18:35	Paul Carlier, Blacksberg, VA Fluorinated methyl ketone oximes: cholinergic and non-cholinergic mechanisms of mosquitocidal action
18:35-18:55	Florian Nachon , Brétigny-sur-Orge Improved nerve agent bioscavenger based on fast spontaneous reactivating swine butyrylcholinesterase
18:55-19:15	Kamil Musilek , Hradec Kralove Monocharged oximes for reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by surrogates of sarin, tabun and VX

Tuesday, December 10
Time	Session/Lecture info
08:00-08:30	Registration & coffee
08:00-08:30
08:30-10:20	Session 6: Cholinergic modulation (1) Chairs: Yishi Jin, La Jolla & Ilan Lampl, Rehovot
08:30-08:50	Ilan Lampl , Rehovot Cholinergic modulation of cortical ongoing and sensory evoked activities
08:50-09:10	Ekaterina Lyukmanova , Moscow The role of human three-finger neuromodulators in the brain cholinergic system
09:10-09:30	Yishi Jin , La Jolla Cholinergic modulation of neuronal excitation and inhibition in C. elegans
09:30-09:50	Millet Treinin , Jerusalem RIC-3, from worms to men and back
09:50-10:20	*Coffee break*
10:20-10:35	In Memory of Eric Barnard Israel Silman, Rehovot & Karl Tsim, Hong Kong
10:20-10:35
10:35-12:15	Session 7: Cholinergic modulation (2) & muscarinic receptors Chairs: Jochen Klein, Frankfurt & Menahem Segal, Rehovot
10:35-10:55	Aharon Lev-Tov , Jerusalem Rhythmogenic networks are potently modulated by activation of M1 M2 and M3 muscarinic acetylcholine receptors in the rodent spinal cord
10:55-11:15	Yoel Yaari , Jerusalem Synaptically-released acetylcholine regulates neuronal 'sodium pump' in brain
11:15-11:35	Jochen Klein , Frankfurt Microdialysis studies of acetylcholine release
11:35-11:55	Jan Jakubik , Prague Novel M2 and M4 selective Gi-biased agonists of muscarinic acetylcholine receptors
11:55-12:15	Jaromir Myslivecek, Prague Striatum, motor cortex and intergeniculate leaflet are the key structures for M4 muscarinic receptor-controlled regulation of the locomotor activity biorhythm
12:15-13:00	Lunch
12:15-13:00
13:00-22:00	Excursion to Jerusalem (including dinner)
13:00-22:00

Wednesday, December 11
Time	Session/Lecture info
08:00-08:30	Registration & coffee
08:00-08:30
08:30-10:20	Session 8: Cholinergic cross talk between neural and immune systems, inflammation Chairs: Marco Prado, London, ON & Dan Frenkel, Tel Aviv
08:30-08:50	Cesare Montecucco , Padova Cholinergic mechanisms in the enteric cross-talk among neurons and immune cells
08:50-09:10	Valentin A. Pavlov , Manhasset, NY Neural cholinergic modulation for treating aberrant inflammation and metabolic derangements
09:10-09:30	Marco Prado, London, ON Cholinergic/glutamatergic co-transmission in the striatum and habitual behavior
09:30-09:50	Steve Brimijoin , Rochester, MN Butyrylcholinesterase and ghrelin in brain
09:50-10:20	*Coffee break*
10:20-12:10	Session 9: Alzheimer disease – cholinergic inhibitors Chairs: Haiyan Zhang, Shanghai & Yifan Han, Hong Kong
10:20-10:40	Ezio Giacobini , Geneva The long march from Skokloster to Rehovot: What do we presently know on the use of cholinesterase inhibitors in the treatment of Alzheimer disease?
10:40-11:00	Yifan Han, Hong Kong Multifunctionally dimeric AChEI for neurodegenerative disorders: from relieving symptoms to modifying diseases
11:00-11:20	Joel Sussman, Rehovot Recent breakthroughs in structure/function studies on acetylcholinesterase
11:20-11:40	Haiyan Zhang , Shanghai Development of novel anticholinesterase therapeutic strategies against Alzheimer’s disease
11:40-12:00	Rongbiao Pi , Guangzhou Advances of multifunctional cholinesterase inhibitors for Alzheimer’s disease: 2017-2019
12:00-12:10	*Short breather*
12:10-13:00	Poster highlights (9 presenters) Chair: Pascale Marchot, Marseille
12:10-13:00	Katarzyna Winek, Israel Yingjie XIA, Hong kong Sebastian Lobentanzer, Germany Muslum Gok, Turkey Gilda Neves, USA Nadav Yayon, Israel Leon Islas, Mexico Christoph Erbacher, Germany Qiyun WU, Hong Kong
13:00-15:00	Lunch break & poster session (even numbers)
13:00-15:00
15:00-16:50	Session 10: Regulation and alternate roles of ChEs Chairs: Lili Anglister, Jerusalem & Rick Rotundo, Miami
15:00-15:20	Rick Rotundo, Miami Active site inhibitors increase acetylcholinesterase at cortical synapses
15:20-15:40	Karl Tsim , Hong Kong Transcriptional regulation of acetylcholinesterase in skin during melanogenesis: an enzyme in controlling skin color
15:40-16:00	Yulong Li , Beijing Spying on cholinergic modulation by constructing genetically-encoded GPCR based sensors
16:00-16:20	Qunhui (Heidi) Xie , Beijing New perspective on regulation of acetylcholinesterase via aryl hydrocarbon receptor
16:20-16:50	*Coffee break*
16:50-17:50	Session 11: Memory, cognition and stress Chair: Lorna Role, Bethesda & Rony Paz, Rehovot
16:50-17:10	Lorna Role , Bethesda Mapping the cholinergic engram of memory and memory loss
17:10-17:30	Vania Prado , London, ON Cholinergic influence in brain pathology and cognition
17:30-17:50	Marina Picciotto , New Haven ACh signaling related to anxiety and depression
19:00-22:00	Gala Dinner
19:00-22:00

Thursday, December 12
Time	Session/Lecture info
08:00-08:30	Registration & coffee
08:00-08:30
08:30-10:40	Session 12: Alzheimer disease Chairs: Agneta Nordberg, Stockholm & Ezio Giacobini, Geneva
08:30-08:50	Agneta Nordberg, Stockholm Mapping the alpha 7 nicotinic receptors in neurodegenerative disorders
08:50-09:10	Changiz Geula, Chicago Basal forebrain cholinergic system: a model of selective neuronal vulnerability in Alzheimer’s disease
09:10-09:30	Dan Frenkel , Tel Aviv Microglia neurotoxicity in AD: diversity vs specificity
09:30-09:50	Taylor Schmitz , London, ON The molecular drivers and neurodegenerative trajectory of preclinical Alzheimer’s disease: Lessons from multimodal longitudinal studies of the human cholinergic basal forebrain system
09:50-10:10	Elizabeth Coulson , Brisbane The role of p75 neurotrophin receptor in cholinergic neuron development and survival
10:10-10:40	*Coffee break*
10:40-11:20	Plenary Lecture
10:40-10:45	Hermona Soreq , Jerusalem Introduction
10:45-11:20	Hiroki R. Ueda , Tokyo Towards organism-level systems biology by next-generation genetics and whole-organ cell profiling
11:20-12:20	Workshop: Cholinergic crisis – Effect of anticholinergic drugs on dementia
11:20-12:20	Panel: Abraham Fisher (Coordinator), Changiz Geula, Ezio Giacobini, Agneta Nordberg, Taylor Schmitz, Palmer Taylor
12:20-14:00	Lunch
12:20-14:00
14:00-16:10	Session 13: Cholinergic involvement in addiction and neurological diseases Chairs: Hermona Soreq, Jerusalem & Changiz Geula, Chicago
14:00-14:20	Henry Lester , Pasadena Inside-out pharmacology of nicotine addiction and smoking cessation drugs
14:20-14:40	Hermona Soreq , Jerusalem Carving the molecular landscape of cholinergic regulators in health and disease
14:40-15:00	Salvatore Carbonetto, Montreal Dystroglycan scaffolds: from neuromuscular junction to neurodevelopmental disorders
15:00-15:30	*Coffee break*
15:30-15:50	Eran Hornstein , Rehovot RNA insufficiency in ALS
15:50-16:10	Joshua Goldberg , Jerusalem An α-synuclein-induced channelopathy in cholinergic motoneurons causes non-motor symptoms in a mouse model of prodromal Parkinson’s disease
16:10-16:30	Best poster awards
16:10-16:30
16:30-16:45	Summary of the meeting Henry lester
16:30-16:45
16:45-17:00	Closing Remarks: Hermona Soreq & Lili Anglister
16:45-17:00