Program

Important Dates

Registration Deadline

April 15, 2016

Abstract Submission Deadline

March 15, 2016

ICSA2016 Program

Sunday, July 3
Time	Session/Lecture info
15:30-21:00	Opening session: Immune surveillance and inflammation Chair: Dorothy Bennett
15:30-16:00	Registration
16:00-16:15	Dorothy Bennett, ICSA President Welcome and introduction
16:15-17:00	Scott Lowe, Memorial Sloan-Kettering Cancer Center Immune surveillance of premalignant senescent cells
17:00-17:25	Angela Santoni, Sapienza University of Rome NK cell-mediated immunosurveillance against drug-induced senescent tumor cells
17:25-17:40	Juan-Carlos Acosta, University of Edinburgh The activation of the Inflammasome by Toll-like receptors (TLRs) regulates Oncogene Induced Senescence
17:40-18:00	Coffee Break
18:00-18:25	Yinon Ben-Neriah, The Hebrew University of Jerusalem Senescence-associated parainflammation
18:25-18:40	Ana O'Loghlen, Queen Mary University Role for integrin beta 3 regulating cellular senescence and ageing through focal adhesion formation
18:40-18:55	Andrew Koff, Memorial Sloan Kettering Cancer Center Biomarker discovery through a molecular understanding of CDK4 inhibitor therapy induced senescence
19:00-21:00	Cocktail Dinner

Monday, July 4
Time	Session/Lecture info
09:00-14:15	Session 1: Senescent cells in physiological and pathophysiological conditions Chair: Manuel Serrano
09:00-09:25	Jan van Deursen, Mayo Clinic How senescent cells drive aging and age-related disease
09:25-09:50	Jennifer Gamble, University of Sydney Medical School and Centenary Institute Inflammation and Endothelial Senescence
09:50-10:05	Tom Bird, University of Edinburgh Inhibition of TGF beta reduces paracrine senescence and improves hepatic regeneration in acute liver injury
10:05-10:20	Maximina Yun, University College London Conserved and novel functions of programmed cellular senescence during vertebrate development
10:20-10:45	Coffee Break
10:45-11:10	Martin Bennett, Univrsity of Cambridge Vascular smooth muscle cell senescence in atherosclerosis
11:10-11:35	Victor J. Thannickal, University of Alabama Myofibroblast Senescence in Fibrotic Lung Disease
11:35-12:00	Valery Krizhanovsky, Weizmann Institute of Science The role of club cells senescence in chronic lung disease
12:00-12:15	Antonio Sarikas, Technical University of Munich Essential role for premature senescence of myofibroblasts in myocardial fibrosis
12:15-14:15	Lunch and Poster session
14:15-21:00	Session 2: Senescence, epigenetics and metabolism Chair: Scott Lowe
14:15-15:00	Daniel Peeper, Netherlands Cancer Institute EMBO Lecture:Oncogene-induced senescence: what if it fails?
15:00-15:25	Peter Adams, University of Glasgow Epigenetics of cell senescence ? insights into aging and cancer
15:25-15:50	Oliver Bischof, Institue Pasteur Dynamic epigenomic and transcriptomic profiling reveal stress-specific senescence states
15:50-16:05	Hannah Walters, University of Oxford Reversal of phenotypes of senescence by pan-mTOR inhibition
16:05-18:00	Coffee and Poster session
18:00-18:25	Gerardo Ferbeyre, University of Montreal Defective ribosome biogenesis in senescence reveals a novel checkpoint pathway to control cyclin-dependent kinases
18:25-18:50	Jesus Gil, Imperial College London The SWI/SNF complex prevents liver cancer by regulating senescence
18:50-19:05	Aaron Mendez-Bermudez, Institute for Research on Cancer and Aging, Nice Role of the telomeric protein TRF2 in heterochromatic replication and cellular senescence
19:05-21:00	Cocktail Dinner

Tuesday, July 5
Time	Session/Lecture info
09:00-10:45	Session 3:Senescence and stem cells Chair: Clemens Schmitt
09:00-09:30	Manuel Serrano, Spanish National Cancer Reasearch Center An integrated view of senescence and reprogramming
09:30-09:55	Pura Muñoz-Cánoves, ICREA/UPF (Barcelona) and CNIC (Madrid) Stem cell senescence in aging muscle
09:55-10:10	Han Li, Institut Pasteur Senescence is critical for injury-induced in vivo reprogramming in skeletal muscle
10:10-10:25	Jacob Goodwin, Karolinska Institutet Loss of CDK2 Inhibits BRAFV600E/MYC-induced mouse lung tumor development
10:25-10:45	Coffee Break
10:45-21:00	Session 4: DNA damage Chair: Judith Campisi
10:45-11:10	Jan Hoeijmakers, Erasmus University Rotterdam Maintaining Nature's Perfection: impact of DNA repair and possibilities for healthy aging
11:10-11:35	Fabrizio d'Adda di Fagagna, IFOM,Milano The role of DNA damage response modulation in cellular senescence
11:35-12:00	Yossi Shiloh, Tel Aviv University The DNA damage response at the crossroads of genome stability, aging and cell senescence
12:00-12:15	Corinne Abbadie, CNRS,Paris A new DNA damage route to senescence and neoplastic escape
12:15-14:15	Lunch & Posters
14:15-21:00	Tour

Wednesday, July 6
Time	Session/Lecture info
09:00-10:45	Session 5: Senescence in the hematopoietic system Chair: Angela Santoni
09:00-09:25	Clemens Schmitt, Max-Delbruck-Center for Molecular Medicine Therapeutic implications of primary and secondary senescence in cancer
09:25-09:50	Daohong Zhou, University of Arkansas for Medical Sciences Clearance of senescent cells rejuvenates aged hematopoietic stem cells
09:50-10:05	Peter de Keizer , Erasmus University Medical Center Selective targeting of senescence through a FOXO4-based peptide to counteract features of aging, chemotoxicity and cancer therapy resistance
10:05-10:20	Muge Ogrunk, INSERM,Paris Molecular Insights of APL cure as therapy-induced Senescence
10:20-10:45	Coffee Break
10:45-14:00	Session 6: Senescence –how many faces after all? Chair: Valery Krizhanovsky
10:45-11:10	Andrei Gudkov, Roswell Park Cancer Institute Biological sense of senescent cells: value and price of their pharmacological eradication
11:10-11:35	Ittai Ben-Porath, The Heberew University of Jerusalem The benefits of aging-associated beta cell senescence
11:35-12:20	Judith Campisi, Buck Institute for Research on Aging Cellular senescence: Quo vadis?
12:20-12:45	Prizes/Fellowships & Wrap up
12:45-14:00	Lunch

Organizing committee

Valery Krizhanovsky

Weizmann Institute of Science, Rehovot, Israel

Ittai Ben-Porath

Hebrew University- Hadassah Medical School, Jerusalem, Israel

Conference Coordinator

Inbal Azoulay

inbal.azoulay@weizmann.ac.il Tel: +972-8-934-4510

Program

Important Dates

Registration Deadline

Abstract Submission Deadline

ICSA2016 Program

Sunday, July 3

Organizing committee

Valery Krizhanovsky

Ittai Ben-Porath

Conference Coordinator

Inbal Azoulay