Speakers

Professor of Pathology and of Microbiology and Immunology and, by courtesy, of Chemical and Systems Biology, Stanford University, Stanford, CA

Research Interest

Bogyo group is made up of a mix of synthetic organic chemists, biochemists, and cell biologists. They use synthetic chemistry to build new reagents that allow protease activity to be monitored in complex biological samples including cells, tissues and whole animals. They are applying these tools to 1) functional studies of cysteine and serine proteases in the life cycle stages of the human parasites Toxoplasma gondii and Plasmodium falciparum 2) in vivo imaging of multiple classes of proteases during the process of tumorigenesis.

Professor, National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry & Biotechnology, Athens, Greece

Research Interest

Chondrogianni laboratory scientific activities focus in the identification of factors and pathways that regulate human aging with particular interest on the regulation of the proteasome and protein degradation during aging and senescence. Has recently started working with the C. elegans model organism.

Professor of Molecular Biology & Biochemistry, USC Leonard Davis School of Gerontolgy, Los Angeles, CA, USA

Executive Vice Dean, Dean of Faculty and Dean of Research
James E. Birren Chair in Gerontology
Director, Ethel Percy Andrus Gerontology Center
Director, USC-Buck Biology of Aging PhD Program

Research Interest

Degradation of oxidatively damaged proteins by the proteasome and the mitochondrial Lon protease.

Professeur, Integrative Cellular Ageing And Inflammation, Institute De Biologie, Paris, France

Research Interest

Our goals are to elucidate the role of protein oxidation as well as oxidized protein degradation and repair during cellular ageing ex vivo and in vitro and in situations of oxidative stress leading to accelerated ageing with relevant human cellular models.

Professor of Cell Biology, Harvard Medical School, Boston, MA, USA

Research Interest

The Goldberg laboratory is attempting to understand why the cell's machinery destroys only damaged proteins, leaving normal proteins untouched. They are also studying how protein breakdown is important in the body's immune defenses, why the destruction process goes into high gear in certain disease states such as cancer, and how this excessive destruction can be controlled.

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, CT, USA

Research Interest

Hochstrasser laboratory is interested in understanding the assembly process of the proteasome because this has important implications for how cells regulate their proteolytic capacity to suit their needs. Moreover, a regulated process such as proteasome assembly can provide an interesting target for pharmacological intervention.

Research Associate, Department of Structural Biology and Biophysics, Institute of Pharmacology and Structural Biology, Toulouse, France

Research Interest

Dr. Marcoux research interests are focused on using mass spectrometry as a tool for studying soluble and membrane associated protein assemblies.

Professor, Head Research Group Immunology and Cell Biology at the Research Center Borstel / Leibniz Lung Center, Borstel, Germany

Chair Immunoproteasome Research at the Christian-Albrechts University in Kiel, Germany

Research Interest

Meiners’ laboratory investigates the role of proteasomal protein degradation in chronic lung diseases.

Assistant Professor In Residence, School of Pharmacy and Pharmaceutical Science, UC San Diego, San Diego, CA, USA

Research Interest

O’Donoghue laboratory interests lie in the detection and characterization of proteolytic enzymes that are involved in disease. In particular, they are interested in understanding the role of peptidases/proteases at host-pathogen and tumor-stroma interfaces.

Professor, Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel

Research Interest

The Sharon group investigates mechanisms that control and coordinate the activity of molecular machines involved in the protein degradation pathway. Using novel native mass spectrometry approaches, in conjunction with fluorescence microscopy, biochemical and cell biology methods - generating an integrative mode of analysis combining in vitro and in vivo findings.

Associate Professor, Department of Biochemistry, West Virginia University Health Sciences, Morgantown, WV, USA

Research Interest

Smith laboratory is interested in understanding how the proteasome moves and functions at a molecular level, using an energy dependent multistep process involving 1) substrate binding, 2) unfolding, 3) translocation, 4) gate-opening and 5) destruction inside of a sequestered chamber. More specifically they have a special interest in understanding how the many different regulatory “caps” that bind to the 20S proteasome catalyze aspects of this multistep process.

Professor, Department of Biology, Institute of Molecular Biology & Biophysics, ETH Zurich, Zurich, Switzerland

Research Interest

Weber-Ban laboratory investigates the structure and function of chaperone-​protease complexes and associated proteins. Recently we have focused our attention on the pup-​proteasome-system.