Program

Protein-Protein Interactions 2017 Program

Sunday, December 3
Time	Session/Lecture info
18:45-20:10	Sunday, December 3rd
18:45-20:00	Dinner
20:00-20:10	Opening address by the organizers
20:10-23:00	Evolution of protein interactions Chair: Brian Baker
20:10-20:40	Andreas Plückthun, University of Zurich An Alternative Strategy to Generate Binding Proteins
20:40-21:10	Emmanuel Levy, Weizmann Institute of Science Proteins evolve on the edge of supramolecular self-assembly
21:10-21:40	Raghavan Varadarajan, Indian Institute of Science Unexpectedly high mutational sensitivity in a gene encoding a natively unfolded protein
21:40-23:00	Get together

Monday, December 4
Time	Session/Lecture info
08:30-11:10	Theory & Computation Chair: Jacob Piehler
08:30-09:00	Rebecca Wade, HITS & Heidelberg University Learning from an electrostatics-centric view of protein-protein interactions
09:00-09:30	Michael Feig, Michigan State University Dynamics of proteins under crowded conditions from computer simulations
09:30-10:00	Ivet Bahar, University of Pittsburgh Adaptability of LeuT-fold superfamily of membrane transporters to allosteric dynamics and functional diversity
10:00-10:20	David Lukatsky, Ben Gurion University of the Negev Design principles and implications of non-consensus protein-DNA binding
10:20-10:40	Barak Raveh, University of California, San Francisco Striking the balance between selectivity and efficiency in nucleocytoplasmic transport
10:40-11:10	Coffee Break
11:10-13:00	Membrane protein complexes Chair: Michael Oliveberg
11:10-11:40	Jacob Piehler, University of Osnabrück Molecular and cellular determinants of cytokine receptor activation
11:40-12:10	Jay T. Groves, University of California, Berkeley Signaling reactions on membrane surfaces
12:10-12:40	Stefan Raunser, MPI Dortmund Dynamics of proteins under crowded conditions from computer simulations
12:40-13:00	Eric Sundberg, University of Maryland The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to translocate its oncoprotein CagA
13:00-16:30	BREAK
16:15-16:30	Coffee Break
16:30-22:00	Design and Engineering Chair: Gideon Schreiber
16:30-17:00	Julia Shifman, The Hebrew University of Jerusalem Mapping of binding landscapes through computation and experiment
17:00-17:30	Sachdev Sidhu, University of Toronto From Antibodies to Synthetic Proteins
17:30-18:00	Sarel Fleishman, Weizmann Institute of Science Computational design of affinity and specificity in protein interactions networks
18:00-18:20	Michal Sharon, Weizmann Institute of Science Measuring inter-protein pairwise interaction energies from a single native mass spectrum by double-mutant cycle analysis
18:20-18:40	Yanay Ofran, Bar-Ilan University "All models are wrong, some are useful": Designing functional antibodies based on multiple wrong models
18:40-19:00	Niv Papo, Ben Gurion University of the Negev Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Mesotrypsin for Cancer Therapy
19:00-20:30	Dinner
20:30-22:00	Poster session I

Tuesday, December 5
Time	Session/Lecture info
08:30-11:10	Structural approaches Chair: Rebecca Wade
08:30-09:00	Meytal Landau, Technion New Structure-activity Paradigms for Amyloids from Pathogenic Microbes
09:00-09:30	Robert Tycko, NIH Fibril formation by amyloid-beta and by low-complexity sequences: Insights from solid state NMR
09:30-10:00	Marcellus Ubbink, Leiden University Transient complexes of redox proteins
10:00-10:20	Alevtyna Yakushevska, Thermo Fisher Indispensable solutions for Cryo Electron Microscopy from Thermo Fisher
10:20-10:40	Ron Diskin, Weizmann Institute of Science Combating Deadly Arenaviruses using Protein Binders: Structure- Based Rational Design of Universal Immunotherapy
10:40-11:10	Coffee Break
11:10-13:00	Intrinsically unstructured protein complexes Chair: Dana Reichmann
11:10-11:40	Assaf Friedler, The Hebrew University of Jerusalem The interplay between structured and disordered domains in proteins
11:40-12:10	Jane Clarke, University of Cambridge Mechanistic Studies of Folding upon Binding using the "Family Approach
12:10-12:40	Huan Xiang Zhou, Florida State University Designed mutations alter the binding pathways of an intrinsically disordered protein
12:40-13:00	Rina Rosenzweig, Weizmann Institute of Science Hsp70 Chaperone-Substrate Interactions
13:00-16:30	BREAK
16:15-16:30	Coffee Break
16:30-22:00	Protein interactions in the cell Chair: Andreas Plückthun
16:30-16:50	Matthias Molnar , NanoTemper Technologies GmbH When binding affinity matters
16:50-17:20	Frank Noe , Freie University of Berlin Reversible protein-protein association in atomic detail
17:20-17:50	Gideon Schreiber, Weizmann Institute of Science Evolutionary constraints on specific and promiscuous protein- protein interactions
17:50-18:20	Michael Oliveberg, Stockholm University Physicochemical code for protein interactions in live cells
18:20-18:40	Dana Reichmann, The Hebrew University of Jerusalem Insights into (un)structure-function relationships.
18:40-19:00	Jens Danielsson, Stockholm University In-cell thermodynamics: modulation of protein stability and the unfolded ensemble by the mammalian cytosolic milieu
19:00-20:30	Dinner
20:30-22:00	Poster session II

Wednesday, December 6
Time	Session/Lecture info
08:30-11:10	Protein-protein interactions in disease and drug development Chair: Assaf Friedler
08:30-09:00	Yasmina Abdiche, Wasatch Microfluidics The role of next generation Array SPRi methods in guiding the discovery of therapeutic antibodies and vaccines
09:00-09:30	Brian Baker, University of Notre Dame Accounting for specificity and cross-reactivity in T cell receptor molecular recognition
09:30-10:00	Ozlem Keskin , Koc University Investigation of KRas dimerization & KRas-effector Interactions
10:00-10:20	Andreas Ernst, Goethe-University Hospital Targeting Ras interactions: Engineered Ras-binding domains as potent competitive inhibitors of oncogenic Ras
10:20-10:40	Jutta Eichler, University of Erlangen-Nurnberg Exploring Protein-Protein Interactions Using Scaffolded and Assembled Peptides as Synthetic Binding Site Mimics
10:40-11:10	Coffee Break
11:10-13:10	System Biology of protein interactions Chair: Meytal Landau
11:10-11:40	Andrew Baldwin, University of Oxford Naturally occurring organic solvents inside cells; membraneless organelles
11:40-12:10	Steve Michnick, Université de Montréal The phases and dephases of endocytosis
12:10-12:30	Emily Baker, Bristol University Engineering Protein Stability with Atomic Precision in a Monomeric Miniprotein: PPα
12:30-12:50	Arie admon, Technion Thousands of protein-peptides interactions in every cell: The MHC peptidome
12:50-13:10	Jonathan Gershoni, Tel Aviv University Profiling the IgOme - the repertoire of antibodies in polyclonal serum
13:10-16:30	BREAK
16:15-16:30	Coffee Break
16:30-19:00	Protein interaction in signal transduction Chair Julia Shifman
16:30-16:50	Ora Schueler-Furman, The Hebrew University of Jerusalem How peptide-mediated interactions obtain affinity and specificity: Integration of information in tandem WW domain- PPXY motif binding
16:50-17:10	Ylva Ivarsson, Uppsala University Discovery of short linear motif-mediated interactions through phage display of intrinsically disordered regions of the human proteome
17:10-17:30	Bohdan Schneider, Institute of Biotechnology CAS New structurally robust protein scaffolds for directed evolution
17:30-18:00	Colin Kleanthous, University of Oxford Protein antibiotic translocation across the Gram-negative outer membrane
18:00-18:20	Mickey Kosloff, University of Haifa Interplay between negative and positive design determines how RGS proteins modulate the inactivation of G-alpha subunits
18:20-18:50	Hartmut Oschkinat, FMP Berlin Investigating PPI by solid-state NMR, and inhibition by small molecules
18:50-19:00	Concluding remarks & plans for the future
20:00-23:00	Farewell dinner and Party
20:00-23:00

Thursday, December 7
Time	Session/Lecture info
08:00-11:00	Departures
08:00-11:00

Program

Protein-Protein Interactions 2017 Program

Sunday, December 3