Program

DBPA 2022 Program

Monday, July 18
Time	Session/Lecture info
12:30-13:30	Welcome & Lunch
12:30-13:30
14:00-15:35	Session 1:Design of supramolecular protein assemblies
14:00-14:40	Todd Yeates, Department of Chemistry and Biochemistry, UCLA, US Origins and recent applications of designed protein cages
14:40-14:55	Rosalie Lipsh, Weizmann Institute of Science Recombining designed modular protein fragments to generate thousands of structurally diverse enzymes
14:55-15:35	Neil King, Institute for Protein Design, University of Washington, US Computational design of novel self-assembling protein nanomaterials
15:35-16:00	Coffee Break
15:35-16:00
16:00-17:35	Session 2: Biology of supramolecular protein assemblies
16:00-16:40	Ayala Shiber, Department of Biology, Technion, Haifa, IL Evolution of protein folding and assembly pathways: deciphering the characteristics of divergent co-translational assembly pathways in atomic resolution
16:40-16:55	Saurav Mallik , Weizmann Institute of Science Co-translational assembly shapes the protein structure and regulation landscape globally
16:55-17:35	Moran Shalev Benami, Weizmann Institute of Science What can we learn from the secrets of the ocean on evolved signaling
17:35-19:30	Welcome reception and dinner
17:35-19:30

Tuesday, July 19
Time	Session/Lecture info
08:30-09:00	Registration& Coffee
08:30-09:00
09:00-10:35	Session 3: Biology, engineering and dynamics of protein networks
09:00-09:40	Ora Schueler-Furman, Department of Microbiology and Molecular Genetics, Hebrew University, IL New ways to view, model, and learn peptide-mediated protein interactions
09:40-09:55	Johannes Venezian, Technion Deciphering the Characteristics of Divergent Co translational Assembly Pathways
09:55-10:35	Amy Keating, Departments of Biology and Biological Engineering, MIT Exploring protein-peptide interaction landscapes
10:35-11:00	Coffee Break
10:35-11:00
11:00-12:35	Biology, engineering and dynamics of protein networks
11:00-11:40	Edward Lemke, Institute of Molecular Biology, GER Decoding Molecular Plasticity in the Dark Proteome
11:40-11:55	Meta Kristin Heidenreich, Weizmann Institute of Science Factors influencing in vivo phase separation
11:55-12:35	Brenda Andrews, Centre for Cellular and Biomolecular Research, University of Toronto, CA Single cell imaging to study proteome dynamics in vivo
12:35-14:00	Lunch
12:35-14:00
14:00-15:00	Cyrus Chothia Lecture- Sarah Teichmann
14:00-15:00
15:00-16:00	Short talk selected from submitted abstracts
15:00-15:15	Hugo Schweke, Weizmann Institute of Science Proteome-wide discovery of homo-oligomerization across domains of life
15:15-15:30	Jerome Tubiana, Tel Aviv University Mapping binding sites onto protein structures with interpretable geometric deep learning
15:30-15:45	Jose Villegas, A Unified Statistical Potential Reveals that Amino Acid Stickiness Governs Nonspecific Recruitment of Client Proteins into Condensates University of Illinois at Chicago
15:45-16:00	Raman Singh, Weizmann Institute of Science Specialized ribosomes and their control of yeast cell physiology
16:00-18:00	Poster Session
16:00-18:00

Wednesday, July 20
Time	Session/Lecture info
08:30-09:00	Morning Coffee
08:30-09:00
09:00-10:35	Session 4: Biophysics of natural and engineered protein assemblies
09:00-09:40	Bert Poolman, Biochemistry Department, University of Groningen, NL Confining effects, structure and dynamics of the bacterial cytoplasm
09:40-09:55	Donna Matsov , Weizmann Institute of Science Ribosome assemblies: not as conserved as advertised?
09:55-10:35	Aurelien Roux, Biochemistry Department, University of Geneva, CH The unique mechanism of ESCRT-III dependent membrane remodelling
10:35-11:00	Coffee Break
10:35-11:00
11:00-12:35	Biophysics of natural and engineered protein assemblies
11:00-11:40	Vicki Wysocki, Department of Chemistry and Biochemistry, Ohio State University, US Native Mass Spectrometry of Protein Assemblies
11:40-11:55	Sacha Pulsford, Australian National University The carbonic anhydrase of cyanobacterial -carboxysomes indicates novel regulation and organisation of microcompartment enzyme cargo
11:55-12:35	Amnon Horovitz , Department of Structural Biology, Weizmann Institute, IL Probing allosteric pathways and protein-protein interactions by native mass spectrometry
12:35-14:00	Lunch
12:35-14:00

Thursday, July 21
Time	Session/Lecture info
08:30-09:00	Morning Coffee
08:30-09:00
09:00-10:35	Session 5: Integrating biology and design in health and disease
09:00-09:40	Deborah Fass, Weizmann Institute of Science Supramolecular Assembly of Mucins in the Construction of Biological Barriers
09:40-09:55	Chelsea Fries, University of Washington Multistate assembly of trimeric proteins into hexagonal 2D arrays and nanotubes
09:55-10:35	Bruno Correia, Institute of Bioengineering, EPFL, Lausanne, CH Surface fingerprint-driven prediction and design of protein-protein interactions
10:35-11:00	Coffee Break
10:35-11:00
11:00-12:35	Integrating biology and design in health and disease
11:00-11:40	Sarel Fleishman, Weizmann Institute of Science Principles for reliable design of therapeutic enzymes, binders and antibodies
11:40-11:55	Kate Kurgan, University of Bristol The design and characterisation of self-assembled peptide bilayers
11:55-12:35	Roman Jerala, Department of Synthetic Biology and Immunology, National Institute of Chemistry in Ljubljana, SLO Designable coiled-coil dimers for protein assemblies and functional regulators
12:35-14:00	Lunch
12:35-14:00
14:00-15:35	Session 6: LLPS: Biology, physics and design
14:00-14:40	Sam Safran, Department of Chemical and Biological Physics, Weizmann Institute, IL Biological phase separation: lessons from physics
14:40-14:55	Yair Harel, Weizmann Institute of Science From disorder to order: phase-separation of an RNA-binding protein
14:55-15:35	Steve Michnick, Department of Biochemistry, University of Montreal, CA Work performed by biomolecular phase separation
15:35-16:00	Coffee Break
15:35-16:00
16:00-17:35	LLPS: Biology, physics and design
16:00-16:40	Gideon Schreiber, Weizmann Institute of Science Specificity determinants of protein assemblies
16:40-16:55	Alex Hilditch, University of Bristol Design of a de novo miniprotein for liquid-liquid phase separation
16:55-17:35	Simon Alberti, Biotechnology Center, Technische Universit?t Dresden, GER Reconstitution of active multicomponent compartments for DNA damage repair

Organizing committee

Dek Woolfson,
University of Bristol
Emmanuel Levy,
Weizmann Institute of Science

Coordinator & Accessibility Issues

Inbal Azoulay
inbal.azoulay@weizmann.ac.il

Program

DBPA 2022 Program

Monday, July 18

Tuesday, July 19

Wednesday, July 20

Thursday, July 21

Organizing committee

Sponsors

Coordinator & Accessibility Issues

meet@WIS